Bradley Krisanits

About Me

Degrees, Licensures and Certifications:

• B.S. – Biochemistry and Molecular Biology, Lebanon Valley College
• M.S. – Biomedical Sciences, Medical University of South Carolina
• Ph.D. – Molecular Cell Biology and Pathology, Medical University of South Carolina

Research Interests:

Dr. Krisanits’ laboratory investigates how exercise influences breast cancer risk, progression, and treatment outcomes. His team seeks to answer critical questions about when breast cancer risk truly begins and how lifestyle factors shape risk at sensitive time points or affect treatment efficacy. The long-term goal of the program is to uncover the molecular mechanisms through which exercise protects against chronic disease and to translate these insights into potential pharmacological strategies for both cancer and non-cancer patients.

A central focus is on the molecular effects of physical activity, including the production and release of the soluble receptor for advanced glycation end-products (sRAGE), a “molecular sponge” that mitigates pro-inflammatory and pro-oxidant environments linked to disease risk and progression. To address these questions, the lab employs techniques spanning cellular, molecular, and organismal systems. These projects not only advance cancer biology but also create opportunities for graduate and undergraduate students to engage in independent, hands-on research.

Selected Publications:

• Krisanits BA, Schuster R, Randise J, Nogueira LM, Lane JT, Panguluri GA, Li H, Helke K, Cuitiño MC, Koivisto C, Spruill L, Ostrowski MC, Anderson SM, Turner DP, Findlay VJ. Pubertal exposure to dietary advanced glycation end products disrupts ductal morphogenesis and induces atypical hyperplasia in the mammary gland. Breast Cancer Res. 2023 Oct 6;25(1):118.
• Krisanits BA, Woods P, Nogueira LM, Woolfork DD, Lloyd CE, Baldwin A, Frye CC, Peterson KD, Cosh SD, Guo QJ, Spruill LS, Lilly MB, Helke K, Li H, Hanna GS, Hamann MT, Thomas C, Ahmed M, Gooz MB, Findlay VJ, Turner DP. Non-enzymatic glycoxidation linked with nutrition enhances the tumorigenic capacity of prostate cancer epithelia through AGE mediated activation of RAGE in cancer associated fibroblasts. Transl Oncol. 2022 Mar;17:101350.